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However, Singer and coworkers, who analyzed pre- and postsynaptic dopamine markers in postmortem striatal tissue, found a signi cant alteration of dopamine uptake mechanisms; more recently, Wolf and colleagues have found that differences in D2 dopamine receptor binding in the head of the caudate nucleus re ected differences in the phenotypic severity of Tourette syndrome These observations, coupled with the facts that L-dopa exacerbates the symptoms of Tourette syndrome and that haloperidol, which blocks dopamine (particularly D2) receptors, is an effective treatment, support the notion of a dopaminergic abnormality in the basal ganglia, more speci cally in the caudate nucleus In this respect, reported instances of compulsive behavior in relation to lesions in the head of the caudate nucleus and its projections from orbitofrontal and cingulate cortices may be pertinent. jquery pdf preview plugin media - How can I convert first page of a pdf as its thumbnail ...
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This method loads the whole pdf though, not just a thumbnail . ... use PHP as described here How do I convert a PDF document to a preview image in PHP? Using the model of Sydenham chorea, a recent line of investigation has implicated streptococcal infection in the genesis of abruptly appearing Tourette syndrome and of less generalized tics in children This association has also been adopted by some authors to explain obsessive-compulsive behavior of sudden and unexplained onset These putative disorders have been summarized by Swedo and colleagues under the acronym PANDAS (pediatric autoimmune neuropsychiatric disorders with streptococcal infection) In a few cases there has been a relapsing course that is similar to that seen in some Sydenham cases This information is intriguing but not con rmed Treatment Two classes of drugs are used in treatment The alpha2-adrenergic agonists clonidine and guanfacine have been useful in several studies, but not in others These are not as potent as the treatment with neuroleptic drugs, but their side effects are far less severe and they are recommended as the rst treatment. javascript pdf preview image jQuery PDF Plugins | jQuery Script
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